Smuggling charges against NIH virologists trigger political uproar

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The charges centre on samples that NIH scientists Vincent Munster and Claude Kwe were carrying when they arrived in Detroit, Michigan, in January after doing research in the Republic of the Congo. Samples tested by the US Federal Bureau of Investigations as of 29 May contained MPXV DNA, according to a criminal complaint, but none were infectious. Such samples do not require an import permit but must be declared to federal officials. According to the complaint, which was brought by the US Department of Justice, Munster and Kwe allegedly failed to declare the samples and then lied to officials about them. Both scientists have pleaded not guilty. Benton Martin, a federal community defender representing Kwe, who had his initial hearing last month, said that his client “is presumed innocent and we will await future proceedings before commenting further”. An attorney for Munster, who is scheduled to appear at an initial hearing 22 July, did not respond to a request for comment. The case is the latest in a string of prosecutions of researchers for smuggling biological samples. It has brought additional scrutiny to Munster and Kwe’s workplace, the NIH’s Rocky Mountain Lab (RML), in Hamilton, Montana, and to the import of pathogens for study. The RML declined to comment, and a spokesperson for the Department of Health and Human Services, which oversees the NIH, declined to provide additional comment because the case is ongoing. Members of Congress have sought an investigation of the lab and introduced legislation to impose severe sentences for smuggling biological agents. “Illegally smuggling dangerous viruses into our country threatens the health and safety of all Americans,” Senator Tom Cotton, a Republican from Arkansas, said in a statement. Some scientists have defended the pair, and argue they did nothing dangerous. Angela Rasmussen, a virologist at the University of Saskatchewan in Canada, noted that inactivating viruses with potent chemicals is a reliable way to render them inert. “You could drink them and not get infected,” she wrote in a blog post. Other researchers agree that inactivated samples pose no risk, and acknowledge the logistical difficulty of moving samples. But “the regulations have to be followed”, says Melanie Ott, a virologist and head of the Gladstone Institutes in San Francisco, California. “The virology community is not standing for taking shortcuts.” Virus trackers Munster, who is the head of the virus ecology section at the National Institute of Allergy and Infectious Diseases (NIAID), is a leading virologist who has spent decades tracking viruses such Ebola1 and more recently, a new strain of MPXV2. In 2020, Munster and Emmie de Wit, an RML virologist who is married to Munster, won a Golden Goose award, which honours obscure research that proves beneficial: they studied coronaviruses in camels3 for years before parlaying their work into research on antiviral treatments for COVID-19. In January, Munster and Kwe did nine days of field work in Congo. When they tried to re-enter the United States, Munster “adamantly denied any biological materials or samples”, according to the federal complaint, and said that he and Kwe were carrying diagnostics. Inactivated MPXV is considered a biological material under import law, but samples of it are used for diagnostics. The FBI complaint says repeatedly that the men’s luggage contained “deactivated monkeypox virus”. It also states, “Munster and Kwe did not present the true identities of the biological materials in their possession and did not provide or possess the necessary certifications. Rather, Munster and Kwe attempted to pass the samples off as unused diagnostics.” Inactivated viral samples also require a certification of deactivation. Munster, who designed protocols to inactivate MPXV4, allegedly told border control the required documents were on his laptop, but the complaint does not make clear whether that was the case. E-mail cache On 5 June, Rand Paul, a Republican senator from Kentucky, released dozens of pages of e-mails between Munster and other scientists about the handling of biological samples. Paul, a frequent critic of former NIAID director Anthony Fauci and a number of other virologists, claims that the correspondence shows a pattern of violations by Munster. In one set of e-mails from 2011, another researcher suggests Munster could “hand carry” viral samples on a commercial flight. The e-mails do not say whether Munster did so. Jean-Paul Gonzalez, a virologist and biosecurity specialist at Georgetown University in Washington DC said that taking samples, even inactivated, on a commercial flight, was a mistake. “We did that 20 years ago,” he says. “We don’t do that any more.” Enjoying our latest content? Log in or create an account to continue Access the most recent journalism from Nature's award-winning team Explore the latest features & opinion covering groundbreaking research