The trials of translating psilocybin treatment from research to practice

A feasibility trial delivering psilocybin-assisted therapy for treatment-resistant depression within the UK health service reports encouraging adherence and safety — it opens future questions about who is reached, where treatment happens and what standards will be needed to sustain it. This is a preview of subscription content, access via your institution Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 12 print issues and online access $259.00 per year only $21.58 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout Subjects References Denee, T. et al. Curr. Med. Res. Opin. 37, 311–319 (2021). Fang, S., Yang, X. & Zhang, W. Front. Psychiatry 15, 1359088 (2024). Goodwin, G. M. et al. J. Clin. Psychiatry 86, 24m15449 (2025). Rucker, J. J. et al. Nat. Med. https://doi.org/10.1038/s41591-026-04541-0 (2026). De Freitas, R. R. et al. Aust. N. Z. J. Psychiatry 59, 128–151 (2025). Thomas, L. et al. Br. J. Gen. Pract. 63, e852–e868 (2013). Hughes, M. E. & Garcia-Romeu, A. eClinicalMedicine 74, 102711 (2024). Ward, T. J. D. G., Burt, H. M. C., Burt, J. H. S. & Manning, R. P. R. J. Racial Ethn. Health Disparities 10, 1669–1681 (2023). Hartogsohn, I. J. Psychopharmacol. 30, 1259–1267 (2016). Petrovitch, D. et al. Curr. Treat. Options Psychiatry 12, 35 (2025). Damschroder, L. J., Reardon, C. M., Widerquist, M. A. O. & Lowery, J. Implement. Sci. 17, 75 (2022). Klaic, M. et al. Implement. Sci. 17, 10 (2022). Author information Authors and Affiliations Corresponding author Ethics declarations Competing interests L.G. leads, as principal investigator, publicly and commercially funded clinical trials using psychedelics, among other components. Rights and permissions About this article Cite this article Galindo, L., Ragnhildstveit, A. & Illingworth, B.J.G. The trials of translating psilocybin treatment from research to practice. Nat Med (2026). https://doi.org/10.1038/s41591-026-04597-y Published: Version of record: DOI: https://doi.org/10.1038/s41591-026-04597-y